Recombinant Human IL-10 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-10 Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues. Source: E.coli Synonyms: B-TCGF, CSIF, TGIF AA Sequence: MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.6 kDa Accession Number: P22301 Gene ID: 3586 crossreactivity: Bacteria, Human, Human + Virus, Monkey, Mouse, Virus References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Lovato, P Title Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. Citation The Journal of Biological Chemistry; 278(19) pg16777-81 PubMed Id 12615922 First Author Zhao, B Title Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF). Citation The Journal of Biological Chemistry; 281(23) pg15757-62 PubMed Id 16606620 First Author Nelson, E A Title Identification of human STAT5-dependent gene regulatory elements based on interspecies homology. Citation The Journal of Biological Chemistry; 281(36) pg26216-24 PubMed Id 16840779 product.subtitle.productreviews Existing reviews Good quality This cytokine works well for our in vitro T cell studies. High quality and consistent results between batches. From: Jacqueline | Date: 8/3/2021 × Good quality This cytokine works well for our in vitro T cell studies. High quality and consistent results between batches. From: Jacqueline | Date: 8/3/2021 Close
