Recombinant Human IL-10

Product Details

Catalog Number: 200-10

Description:

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

Source: E.coli

Synonyms: B-TCGF, CSIF, TGIF

AA Sequence: MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED₅₀ was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.

Cross Reactivity:

Bacteria, Human , Human + Virus, Monkey, Mouse, Virus

Research Interest

Stem Cells & Differentiation

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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1 Oct 2011

21890660
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Schilling, B

IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.

Journal of molecular medicine (Berlin, Germany); 90(2) pg139-47

0 Feb 2012

21915712
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Jourdan, M

Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation.

Journal of immunology (Baltimore, Md. : 1950); 187(8) pg3931-41

15 Oct 2011

21918187
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Agbanoma, G

Production of TNF-Î± in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.

Journal of immunology (Baltimore, Md. : 1950); 188(3) pg1307-17

1 Feb 2012

22219323
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Hoeve, M A

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation.

PLoS ONE; 7(1) pge29443

0 2012

22238612
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Comas-Casellas, E

Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors.

The Journal of Biological Chemistry; 287(13) pg9682-93

23 Mar 2012

22291008
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Joo, H

Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation.

The Journal of Experimental Medicine; 209(7) pg1335-48

2 Jul 2012

22689824
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Mariante, R M

Neuroimmunoendocrine regulation of the prion protein in neutrophils.

The Journal of Biological Chemistry; 287(42) pg35506-15

12 Oct 2012

22910907
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Mandapathil, M

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.

Oncoimmunology; 1(5) pg659-669

1 Aug 2012

22934258
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Zizzo, G

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.

Journal of immunology (Baltimore, Md. : 1950); 189(7) pg3508-20

1 Oct 2012

22942426
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Gupta, M

Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.

Blood; 120(22) pg4400-6

22 Nov 2012

23018644
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Shi, B

HBsAg inhibits IFN-Î± production in plasmacytoid dendritic cells through TNF-Î± and IL-10 induction in monocytes.

PLoS ONE; 7(9) pge44900

0 2012

23024774
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Braun, D A

Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.

The Journal of Biological Chemistry; 288(5) pg2986-93

1 Feb 2013

23166328
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Malavige, G N

Cellular and cytokine correlates of severe dengue infection.

PLoS ONE; 7(11) pge50387

0 2012

23209731
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Li, Z

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Journal of immunology (Baltimore, Md. : 1950); 190(5) pg2335-44

1 Mar 2013

23359498
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Zhao, M

IL-10 reduces levels of apoptosis in Toxoplasma gondii-infected trophoblasts.

PLoS ONE; 8(2) pge56455

0 2013

23418570
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Zizzo, G

IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.

Journal of immunology (Baltimore, Md. : 1950); 190(10) pg5237-46

15 May 2013

23596310
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Richardson, C L

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

The Journal of Clinical Investigation; 123(8) pg3614-23

0 Aug 2013

23863711
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Seow, V

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Journal of immunology (Baltimore, Md. : 1950); 191(8) pg4308-16

15 Oct 2013

24043889
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Liu, B

IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-ÎºB pathway in human B cells to boost antibody production.

Journal of immunology (Baltimore, Md. : 1950); 191(8) pg4086-94

15 Oct 2013

24043893
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Berglund, L J

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

Blood; 122(24) pg3940-50

5 Dec 2013

24159173
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Freeman, S R

ABCG1-mediated generation of extracellular cholesterol microdomains.

Journal of Lipid Research; 55(1) pg115-27

0 Jan 2014

24212237
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van de Garde, M D

Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction.

Journal of immunology (Baltimore, Md. : 1950); 192(3) pg1196-208

1 Feb 2014

24395918
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Naji, A

Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses.

Journal of immunology (Baltimore, Md. : 1950); 192(4) pg1536-46

15 Feb 2014

24453251
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Herter, S

Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.

Journal of immunology (Baltimore, Md. : 1950); 192(5) pg2252-60

1 Mar 2014

24489098
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Wong, T W

Eosinophils regulate peripheral B cell numbers in both mice and humans.

Journal of immunology (Baltimore, Md. : 1950); 192(8) pg3548-58

15 Apr 2014

24616476
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Ghamlouch, H

Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.

Immunology and Cell Biology; 92(7) pg591-604

0 Aug 2014

24797583
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Williams, G R

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.

The Journal of Experimental Medicine; 211(6) pg1019-25

2 Jun 2014

24799501
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Zhu, S

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.

Blood; 124(3) pg403-11

17 Jul 2014

24891320
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Fecteau, J

Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53.

Blood; 124(10) pg1637-44

4 Sep 2014

24990888
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Yu, J

Noncanonical NF-ÎºB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.

Journal of immunology (Baltimore, Md. : 1950); 193(5) pg2574-86

1 Sep 2014

25063873
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Stephen, T L

Transforming growth factor Î²-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity; 41(3) pg427-439

18 Sep 2014

25238097
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Wehrli, M

Human IgA Fc receptor FcÎ±RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.

Journal of immunology (Baltimore, Md. : 1950); 193(11) pg5649-59

1 Dec 2014

25339672
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Wang, S

PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy.

Cell death & disease; 6 pge1738

7 May 2015

25950468
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Xiu, B

IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.

Blood Cancer Journal; 5 pge328

31 Jul 2015

26230952
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Baruch, K

Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.

Nature Communications; 6 pg7967

18 Aug 2015

26284939
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Su, S

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.

Nature Communications; 6 pg8523

5 Oct 2015

26436920
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Tsuchimoto, Y

M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria-Associated Sepsis in Alcoholics.

Journal of immunology (Baltimore, Md. : 1950); 195(11) pg5169-77

1 Dec 2015

26525287
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Liu, T

Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells.

Scientific Reports; 5 pg16760

13 Nov 2015

26565726
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Shi, J

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.

Cell death & disease; 7 pge2133

10 Mar 2016

26962683
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DeKosky, B J

Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.

Proceedings of the National Academy of Sciences of the United States of America; 113(19) pgE2636-45

10 May 2016

27114511
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Michlmayr, D

Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.

Journal of immunology (Baltimore, Md. : 1950); 196(11) pg4622-31

1 Jun 2016

27183602
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Tuccitto, A

Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.

Stem cells (Dayton, Ohio); 34(10) pg2449-2460

0 Oct 2016

27301067
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Huynh, L

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.

Scientific Reports; 6 pg31959

25 Aug 2016

27558590
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Chorny, A

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

The Journal of Experimental Medicine; 213(10) pg2167-85

19 Sep 2016

27621420
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Cantaert, T

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.

The Journal of Clinical Investigation; 126(11) pg4289-4302

1 Nov 2016

27701145
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Chevrier, S

An Immune Atlas of Clear Cell Renal Cell Carcinoma.

Cell; 169(4) pg736-749.e18

4 May 2017

28475899
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Magri, G

Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals.

Immunity; 47(1) pg118-134.e8

18 Jul 2017

28709802
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Pierog, P L

Toxoplasma gondii

Journal of immunology (Baltimore, Md. : 1950); 200(1) pg186-195

1 Jan 2018

29180487
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Smith, C

IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4

Journal of immunology (Baltimore, Md. : 1950); 200(5) pg1580-1592

1 Mar 2018

29367208
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Zhong, Q

IgG Immunocomplexes Sensitize Human Monocytes for Inflammatory Hyperactivity via Transcriptomic and Epigenetic Reprogramming in Rheumatoid Arthritis.

Journal of immunology (Baltimore, Md. : 1950); 200(12) pg3913-3925

15 Jun 2018

29712771
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Nemoto, M

Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia.

Scientific Reports; 8(1) pg6956

3 May 2018

29725107
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Ohradanova-Repic, A

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.

Frontiers in Immunology; 9 pg852

0 2018

29780382
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Silvola, J M

Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.

Scientific Reports; 8(1) pg9720

26 Jun 2018

29946129
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Pan, Y

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas.

Nature Communications; 9(1) pg3696

12 Sep 2018

30209389
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Aden, K

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

The Journal of Experimental Medicine; 215(11) pg2868-2886

5 Nov 2018

30254094
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Proto, J D

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.

Immunity; 49(4) pg666-677.e6

16 Oct 2018

30291029
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Kucharzik, T

Immunoregulatory properties of IL-13 in patients with inflammatory bowel disease; comparison with IL-4 and IL-10.

Clinical and Experimental Immunology; 104(3) pg483-90

0 Jun 1996

9099934
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Kucharzik, T

IL-4, IL-10 and IL-13 down-regulate monocyte-chemoattracting protein-1 (MCP-1) production in activated intestinal epithelial cells.

Clinical and Experimental Immunology; 111(1) pg152-7

0 Jan 1998

9472675
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Gorczynski, R M

Analysis of cytokine production and V beta T-cell receptor subsets in irradiated recipients receiving portal or peripheral venous reconstitution with allogeneic bone marrow cells, with or without additional anti-cytokine monoclonal antibodies.

Immunology; 93(2) pg221-9

0 Feb 1998

9616372
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Hirohata, S

Human Th1 responses driven by IL-12 are associated with enhanced expression of CD40 ligand.

Clinical and Experimental Immunology; 115(1) pg78-85

0 Jan 1999

9933423
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Yoshida, T

Acceleration of R5 HIV replication by polymorphonuclear neutrophils in cultures of macrophages.

Immunology and Cell Biology; 85(3) pg215-9

0 Apr 2007

17213833
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Fernández de Marco, M d

The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 24(5) pg1479-88

0 May 2010

20019241
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Lügering, N

Interleukin-15 strongly inhibits interleukin-8 and monocyte chemoattractant protein-1 production in human colonic epithelial cells.

Immunology; 98(4) pg504-9

0 Dec 1999

10594681
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Cobos Jiménez, V

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.

Scientific Reports; 2 pg763

0 2012

23094138
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Rodríguez-Bayona, B

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

Journal of immunology (Baltimore, Md. : 1950); 191(10) pg4996-5004

15 Nov 2013

24101550
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Jahrsdörfer, B

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.

Blood; 115(6) pg1156-65

11 Feb 2010

19965634
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Fernández de Marco, M d

The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 24(5) pg1479-88

0 May 2010

20019241
Show Usages

Jahrsdörfer, B

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.

Blood; 115(6) pg1156-65

11 Feb 2010

19965634
Show Usages

Lügering, N

Interleukin-15 strongly inhibits interleukin-8 and monocyte chemoattractant protein-1 production in human colonic epithelial cells.

Immunology; 98(4) pg504-9

0 Dec 1999

10594681
Show Usages

Cobos Jiménez, V

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.

Scientific Reports; 2 pg763

0 2012

23094138
Show Usages

Rodríguez-Bayona, B

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

Journal of immunology (Baltimore, Md. : 1950); 191(10) pg4996-5004

15 Nov 2013

24101550
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Meng, X

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

Nature; 564(7734) pg130-135

1 Dec 2018

30487606
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Georgouli, M

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.

Cell; 176(4) pg757-774.e23

7 Feb 2019

30712866
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Schulz, D

In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.

Scientific Reports; 9(1) pg1925

13 Feb 2019

30760760
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Growth Factors & Cytokines