Growth Factors & Cytokines

Recombinant Human IL-13

Product Details

Catalogue Number: 200-13
Description:

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 are cross-species reactive.  Recombinant Human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues.

Source: E.coli

Synonyms: NC30 (Human), P600 (Murine)

AA Sequence: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 12.6 kDa

Accession Number: P35225

Gene ID: 3596

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Volpert, O V
Title
Inhibition of angiogenesis by interleukin 4.
Citation
The Journal of Experimental Medicine; 188(6) pg1039-46
PubMed Id
First Author
Hikida, M
Title
Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor.
Citation
The Journal of Experimental Medicine; 188(2) pg365-72
PubMed Id
First Author
Kucharzik, T
Title
IL-4, IL-10 and IL-13 down-regulate monocyte-chemoattracting protein-1 (MCP-1) production in activated intestinal epithelial cells.
Citation
Clinical and Experimental Immunology; 111(1) pg152-7
PubMed Id

product.subtitle.productreviews

Existing reviews
Good
I have used the vial before in the lab, and have got the desired results. that is why I have ordwred the same vial again. because I trust the product
From:  E | Date:  8/27/2020