Animal-Free Recombinant Human IL-15 0 ReviewsSubmit a Review Product Details Catalog Number: AF-200-15 Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-15, IL-T AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.9 kDa Accession Number: P40933 Gene ID: 3600 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Human + Hamster, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell AIDS/HIV Apoptosis Cancer Cell Culture Immune System Neurobiology Stem Cells & Differentiation Recent Citations First Author Eichholz, K Title A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue Citation Scientific Reports; 11(1) pg12921 PubMed ID 34155235 First Author Kluesner, M G Title CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells Citation Nature Communications; 12(1) pg2437 PubMed ID 33893286 First Author Weng, R R Title Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer Citation Nature Communications; 12(1) pg2163 PubMed ID 33846331
