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Animal-Free Cytokines

Animal-Free Recombinant Human IL-15

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Product Details

Catalogue Number: AF-200-15
Description:
Animal-Free Recombinant Human IL-15

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2.  IL-15 exerts its biological activities primarily on T cells.  It is also essential in the development, survival and activation of NK cells.  Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I.  Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.  Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Interleukin-15, IL-T

AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Animal-Free Recombinant Human IL-15 Biological Activity Graph

Calculated Molecular Weight: 12.9 kDa

Accession Number: P40933

Gene ID: 3600

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Eichholz, K
Title
A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue
Citation
Scientific Reports; 11(1) pg12921
PubMed Id
First Author
Kluesner, M G
Title
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells
Citation
Nature Communications; 12(1) pg2437
PubMed Id
First Author
Weng, R R
Title
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
Citation
Nature Communications; 12(1) pg2163
PubMed Id