Recombinant Human IL-17B 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-28 Description: IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T cells, and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant Human IL-17B is a 36.6 kDa non-disulfide-linked homodimer of two 161 amino acid polypeptide chains. Source: E.coli Synonyms: IL20, NIRF AA Sequence (monomer): MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Note: Results may vary with PBMC donors. Calculated Molecular Weight: 36.6 kDa Accession Number: Q9HF5 Gene ID: 27190 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Immune System product.subtitle.recentcitations First Author Silacci, M Title Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency. Citation The Journal of Biological Chemistry; 289(20) pg14392-8 PubMed Id 24692552
