Recombinant Human IL-2 6 ReviewsSubmit a Review Product Details Catalogue Number: 200-02 Description: IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. Source: E.coli Synonyms: Interleukin-2, T-cell growth factor (TCGF), Aldesleukin AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15.5 kDa Accession Number: P60568 Gene ID: 3558 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Cow, Cow + Mouse, Dog, Human, Human + Hamster, Human + Mouse, Human + Virus, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Ma, Y Title Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19. Citation International Immunopharmacology; 112 pg109283 PubMed Id 36201943 First Author Karagiannis, F Title Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Citation Nature; 609(7928) pg801-807 PubMed Id 35901960 First Author Wang, W Title Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors. Citation Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(22) pge2105810 PubMed Id 35665491 product.subtitle.productreviews Existing reviews Excellent for Treg culture Very good for culture of human sorted Tregs, consistent across lots and vials. From: Julian | Date: 7/10/2020 × Excellent for Treg culture Very good for culture of human sorted Tregs, consistent across lots and vials. From: Julian | Date: 7/10/2020 Close hIL-2 Great product, works well to stimulate primary human T cells (tested for up to 2 weeks in culture). From: Kimberly | Date: 8/10/2020 × hIL-2 Great product, works well to stimulate primary human T cells (tested for up to 2 weeks in culture). From: Kimberly | Date: 8/10/2020 Close T cell culture Used in culturing primary human T cells - works great! From: Elizabeth | Date: 8/26/2020 × T cell culture Used in culturing primary human T cells - works great! From: Elizabeth | Date: 8/26/2020 Close hIL2 Very good product for culturing T cells in vitro. Works great. From: Kevin | Date: 8/26/2020 × hIL2 Very good product for culturing T cells in vitro. Works great. From: Kevin | Date: 8/26/2020 Close Primary T cells Worked well in expanding activated primary T cells. Customer service was great when I wanted to know its equivalent IU values. From: Adam | Date: 8/27/2020 × Primary T cells Worked well in expanding activated primary T cells. Customer service was great when I wanted to know its equivalent IU values. From: Adam | Date: 8/27/2020 Close Works just fine Aliquoted as recommended and worked just fine for several months. From: Tanja | Date: 8/27/2020 × Works just fine Aliquoted as recommended and worked just fine for several months. From: Tanja | Date: 8/27/2020 Close
