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Growth Factors & Cytokines

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Recombinant Human IL-2

Product Details

Catalog Number: 200-02
Description:

IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Source: E.coli

Synonyms: Interleukin-2, T-cell growth factor (TCGF), Aldesleukin

AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

Calculated Molecular Weight: 15.5 kDa

Accession Number: P60568

Gene ID: 3558

Cross Reactivity Cited in References:
Bacteria, Chicken, Cow, Cow + Mouse, Dog, Human, Human + Hamster, Human + Mouse, Human + Virus, Monkey, Mouse, Rat
Research Interest
CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation
References References
PubMed PubMed
SDS SDS
Product Line Product Line

Country Of Origin: USA

Not for human use.

Product Reviews

Existing reviews
Excellent for Treg culture
Very good for culture of human sorted Tregs, consistent across lots and vials.
From:  Julian | Date:  7/10/2020
hIL-2
Great product, works well to stimulate primary human T cells (tested for up to 2 weeks in culture).
From:  Kimberly | Date:  8/10/2020
T cell culture
Used in culturing primary human T cells - works great!
From:  Elizabeth | Date:  8/26/2020
hIL2
Very good product for culturing T cells in vitro. Works great.
From:  Kevin | Date:  8/26/2020
Primary T cells
Worked well in expanding activated primary T cells. Customer service was great when I wanted to know its equivalent IU values.
From:  Adam | Date:  8/27/2020
Works just fine
Aliquoted as recommended and worked just fine for several months.
From:  Tanja | Date:  8/27/2020