Animal-Free Recombinant Human IL-2 0 ReviewsSubmit a Review Product Details Catalog Number: AF-200-02 Description: IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-2, T-cell growth factor (TCGF), Aldesleukin AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15.5 kDa Accession Number: P60568 Gene ID: 3558 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Cow + Mouse, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation Recent Citations First Author Laucirica, D R Title Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection. Citation Immunology and Cell Biology; 100(5) pg352-370 PubMed ID 35318736 First Author Freed-Pastor, W A Title The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. Citation Cancer Cell; 39(10) pg1342-1360.e14 PubMed ID 34358448 First Author Inano, T Title Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia Citation Scientific Reports; 11(1) pg17702 PubMed ID 34489506
