Recombinant Human IL-20 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-20 Description: IL-20 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20Rα and type II IL-20Rβ. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant Human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains. Source: E.coli Synonyms: Interleukin-20, Cytokine ZCYTO10 AA Sequence (monomer): MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to activate STAT following receptor ligand interaction. Calculated Molecular Weight: 35.2 kDa Accession Number: Q9NYY1 Gene ID: 50604 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Inflammation Allergy product.subtitle.recentcitations First Author Schilling, B Title IRX-2, a novel immunotherapeutic, enhances functions of human dendritic cells. Citation PLoS ONE; 8(2) pge47234 PubMed Id 23408925 First Author Zenewicz, L A Title Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Citation Immunity; 29(6) pg947-57 PubMed Id 19100701
