Recombinant Human IL-3 1 ReviewsSubmit a Review Product Details Catalog Number: 200-03 Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. Source: E.coli Synonyms: Interleukin-3, MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15 kDa Accession Number: P08700 Gene ID: 3562 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Human, Human + Hamster, Human + Mouse, Human + Virus, Leech, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Cancer Diabetes/Weight Regulation Immune System Stem Cells & Differentiation Recent Citations First Author Thomas, G E Title The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness. Citation Nature Cell Biology; 24(6) pg872-884 PubMed ID 35668135 First Author Ackermann, M Title Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors. Citation Nature Protocols; 17(2) pg513-539 PubMed ID 35039668 First Author Wang, Y Title Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis. Citation Communications Biology; 5(1) pg72 PubMed ID 35058565 Product Reviews Existing reviews IL3 for iPSC differentiation Much cheaper than other options present in the market and extremely efficient. I'd highly recommend it as it is easy to reconstitute and very dependable. From: Meenakshi | Date: 7/9/2020 × IL3 for iPSC differentiation Much cheaper than other options present in the market and extremely efficient. I'd highly recommend it as it is easy to reconstitute and very dependable. From: Meenakshi | Date: 7/9/2020 Close
