Recombinant Human IL-3 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-03 Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. Source: E.coli Synonyms: Interleukin-3, MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15 kDa Accession Number: P08700 Gene ID: 3562 crossreactivity: Bacteria, Human, Human + Hamster, Human + Mouse, Human + Virus, Leech, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Cancer Diabetes/Weight Regulation Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author Kauts, M Title Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. Citation Stem Cell Reports; 11(4) pg1009-1020 PubMed Id 30197119 First Author Tusa, I Title Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells. Citation Stem Cell Reports; 11(4) pg929-943 PubMed Id 30245209 First Author Lombardo, G Title Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action. Citation Scientific Reports; 6 pg25689 PubMed Id 27157262 product.subtitle.productreviews Existing reviews IL3 for iPSC differentiation Much cheaper than other options present in the market and extremely efficient. I'd highly recommend it as it is easy to reconstitute and very dependable. From: Meenakshi | Date: 7/9/2020 × IL3 for iPSC differentiation Much cheaper than other options present in the market and extremely efficient. I'd highly recommend it as it is easy to reconstitute and very dependable. From: Meenakshi | Date: 7/9/2020 Close
