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Animal-Free Cytokines

Animal-Free Recombinant Human IL-8 (CXCL8) (72 a.a.)

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Product Details

Catalog Number: AF-200-08M
Description:
Animal-Free Recombinant Human IL-8 (CXCL8) (72 a.a.)

IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant Human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: CXCL8, monocyte-derived neutrophil chemotactic factor (MDNCF), neutrophil activating factor (NAF), NAP-1

AA Sequence: SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.4 kDa

Accession Number: P10145

Gene ID: 3576

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

Cross Reactivity Cited in References:
Country Of Origin: USA

Not for human use.

Research Interest

Recent Citations

First Author
Whittall, C
Title
A chemokine self-presentation mechanism involving formation of endothelial surface microstructures.
Citation
Journal of immunology (Baltimore, Md. : 1950); 190(4) pg1725-36
PubMed ID
First Author
Madenspacher, J H
Title
Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.
Citation
The Journal of Biological Chemistry; 287(52) pg43730-40
PubMed ID
First Author
Raghuwanshi, S K
Title
The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.
Citation
Journal of immunology (Baltimore, Md. : 1950); 189(6) pg2824-32
PubMed ID