Growth Factors & Cytokines

Recombinant Human KGF (FGF-7)

Product Details

Catalogue Number: 100-19
Description:

KGF (FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF (FGF-7) is a mitogen factor specific for epithelial cells and keratinocytes. KGF (FGF-7) signals through FGFR 2b. KGF (FGF-7) plays a role in kidney and lung development, as well as in angiogenesis and wound healing. Recombinant Human KGF (FGF-7) is an 18.9 kDa protein consisting of 163 amino acid residues.

Source: E.coli

Synonyms: Keratinocyte Growth Factor, Fibroblast Growth Factor-7, HBGF-7

AA Sequence: CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using 4MBr-5 cells. The expected ED50 for this effect is 0.1-15 ng/ml.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 18.9 kDa

Accession Number: P21781

Gene ID: 2252

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Busslinger, G A
Title
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.
Citation
Cell Reports; 34(10) pg108819
PubMed Id
First Author
Zhang, X
Title
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Citation
The Journal of Biological Chemistry; 281(23) pg15694-700
PubMed Id
First Author
Yang, J
Title
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation.
Citation
Stem Cell Reports; 15(3) pg694-705
PubMed Id

product.subtitle.productreviews

Existing reviews
It works well
It works well both in human and mouse organoid culture.
From:  Eun Joo | Date:  7/8/2020
Excellent quality
We utilize FGF7 as part of lung cancer organoid media for cancers which do not have EGFR mutations. We have had great results and excellent service.
From:  Dora | Date:  7/24/2020
Great for organoids!
We use this in two types patient tumor organoid media and have wonderful results in each.
From:  Julie-Ann | Date:  8/3/2021