Recombinant Human MIA 0 ReviewsSubmit a Review Product Details Catalog Number: 130-01 Description: MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family, MIA, MIA-2, OTOR and TANGO, each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein, secreted from chondrocytes and malignant melanoma cells, that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis, as well as a potential marker for rheumatoid arthritis. Recombinant Human MIA is a 12.2 kDa globular protein containing 108 amino acid residues, including two intramolecular disulfide bonds. Source: E.coli AA Sequence: MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ Synonyms: Melanoma Inhibitory Activity, Cartilage-derived retinoic acid-sensitive protein (CD-RAP) Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4-6 μg/ml. Calculated Molecular Weight: 12.2 kDa Accession Number: Q16674 Gene ID: 8190 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Cancer Immune System Recent Citations First Author Yu-Lee, L Title Bone secreted factors induce cellular quiescence in prostate cancer cells. Citation Scientific Reports; 9(1) pg18635 PubMed ID 31819067 First Author Kolanczyk, M Title MIA is a potential biomarker for tumour load in neurofibromatosis type 1. Citation BMC Medicine; 9 pg82 PubMed ID 21726432
