Recombinant Human Midkine 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-16 Description: Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis. Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds. Source: E.coli Synonyms: MK, NEGF-2 AA Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml. Calculated Molecular Weight: 13.4 kDa Accession Number: P21741 Gene ID: 4192 crossreactivity: Bacteria, Hagfish, Human, Mouse, Pig, Shark, Squid References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Weckbach, L T Title Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. Citation The Journal of Experimental Medicine; 216(2) pg350-368 PubMed Id 30647120 First Author Deepa, S S Title Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. Citation The Journal of Biological Chemistry; 279(36) pg37368-76 PubMed Id 15226297 First Author Nandini, C D Title Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors. Citation The Journal of Biological Chemistry; 279(49) pg50799-809 PubMed Id 15385557
