Growth Factors & Cytokines

Recombinant Human MIF

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Product Details

Catalogue Number: 300-69
Description:
Recombinant Human MIF

Macrophage migration inhibitory factor (MIF) is a small secreted protein that can act as a pleiotropic pro-inflammatory cytokine, as well as an enzyme. MIF pro-inflammatory activity can be initiated by signaling through CD74 and CD44, resulting in the secretion of TNF-a, IL-1, IL-6, IL-8, and various MMPs. The enzymatic activity of MIF is characterized by its ability to act as a tautomerase, capable of catalyzing the keto-to-enol isomerization of keto-phenylpyruvate and L-dopachrome.  It appears as though MIF catalytic activity is dependent upon a trimeric configuration and a free N-terminal proline residue. Insect cell-derived Recombinant Human MIF is a 15 kDa protein containing 124 amino acid residues, including an N-terminal His-tag.

Source: Hi-5 Insect cells

Synonyms: Macrophage Migration Inhibitory Factor, GLIF, MMIF, GIF, Glycosylation-inhibiting factor

AA Sequence: HHHHHHHHAM PMFIVNTNVP RASVPDGFLS ELTQQLAQAT GKPPQYIAVH VVPDQLMAFG GSSEPCALCS LHSIGKIGGA QNRSYSKLLC GLLAERLRIS PDRVYINYYD MNAANVGWNN STFA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit monocyte migration.

Calculated Molecular Weight: 15 kDa

Accession Number: P14174

Gene ID: 4282

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Cunningham, S
Title
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Citation
Transfusion; 61(6) pg1845-1855
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First Author
Zhang, L
Title
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Citation
Cell; 181(2) pg442-459.e29
PubMed Id
First Author
Stephenson, S
Title
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Citation
Journal of immunology (Baltimore, Md. : 1950); 202(4) pg1287-1300
PubMed Id