Recombinant Human Neurturin 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-11 Description: Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, artemin, and persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. The functional form of human neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine-knot configuration. Source: E.coli Synonyms: NTN, NRTN AA Sequence (monomer): ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons. Note: 1mg will be provided as 2x500μg. Calculated Molecular Weight: 23.6 kDa Accession Number: Q99748 Gene ID: 4902 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Hedstrom, K L Title Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling. Citation Proceedings of the National Academy of Sciences of the United States of America; 111(6) pg2325-30 PubMed Id 24449858 First Author Schmutzler, B S Title Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization. Citation Molecular Pain; 7 pg22 PubMed Id 21450093 First Author Bespalov, M M Title Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin. Citation The Journal of Cell Biology; 192(1) pg153-69 PubMed Id 21200028
