Neurotrophins

Recombinant Human NT-3

Product Details

Catalogue Number: 450-03
Description:
Recombinant Human NT-3

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).

Source: E.coli

Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve Growth Factor-2 (NGF-2), HGNF

AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Calculated Molecular Weight: 27.2 kDa

Accession Number: P20783

Gene ID: 4908

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
He, Z
Title
Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons.
Citation
Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(13) pge2104682
PubMed Id
First Author
Yun, W
Title
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.
Citation
NPJ Regenerative Medicine; 7(1) pg4
PubMed Id
First Author
Li, Z
Title
Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
Citation
The Journal of Clinical Investigation; 132(1)
PubMed Id

product.subtitle.productreviews

Existing reviews
I have used PeproTech NT-3 since 2012
Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation!
From:  Louise | Date:  8/21/2020
Recombinant Human NT-3
This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality.
From:  Aala | Date:  8/26/2020