Recombinant Human NT-3

Product Details

Catalog Number: 450-03

Description:

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).

Source: E.coli

Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve growth factor-2, NGF-2, HGNF

AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.

Calculated Molecular Weight: 27.2 kDa

Accession Number: P20783

Gene ID: 4908

Cross Reactivity Cited in References:

Chicken, Cow, Dog, Frog, Hamster, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat

Research Interest