Recombinant Human NT-3 2 ReviewsSubmit a Review Product Details Catalogue Number: 450-03 Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Source: E.coli Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve Growth Factor-2 (NGF-2), HGNF AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Calculated Molecular Weight: 27.2 kDa Accession Number: P20783 Gene ID: 4908 crossreactivity: Chicken, Cow, Dog, Frog, Hamster, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Truvé, K Title Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder Citation Translational Psychiatry; 10(1) pg390 PubMed Id 33168801 First Author Bayó-Puxan, N Title Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons. Citation Scientific Reports; 8(1) pg16644 PubMed Id 30413728 First Author Nzou, G Title Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. Citation Scientific Reports; 8(1) pg7413 PubMed Id 29743549 product.subtitle.productreviews Existing reviews I have used PeproTech NT-3 since 2012 Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation! From: Louise | Date: 8/21/2020 × I have used PeproTech NT-3 since 2012 Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation! From: Louise | Date: 8/21/2020 Close Recombinant Human NT-3 This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality. From: Aala | Date: 8/26/2020 × Recombinant Human NT-3 This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality. From: Aala | Date: 8/26/2020 Close
