Animal-Free Recombinant Human NT-3 0 ReviewsSubmit a Review Product Details Catalog Number: AF-450-03 Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve growth factor-2, NGF-2, HGNF AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Calculated Molecular Weight: 27.2 kDa Accession Number: P20783 Gene ID: 4908 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Neurobiology Stem Cells & Differentiation Recent Citations First Author Feng, L Title Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs. Citation Advanced science (Weinheim, Baden-Wurttemberg, Germany); 7(23) pg2002155 PubMed ID 33304759 First Author Floriddia, E M Title Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury. Citation Nature Communications; 11(1) pg5860 PubMed ID 33203872 First Author Zhang, W Title Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation. Citation Stem Cell Reports; 15(1) pg185-197 PubMed ID 32502463
