Recombinant Human NT-4 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-04 Description: NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors, and promotes the survival of peripheral sensory sympathetic neurons. Recombinant Human NT-4 is a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues). Source: E.coli Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5) AA Sequence (monomer): GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Calculated Molecular Weight: 28.1 kDa Accession Number: P34130 Gene ID: 4909 crossreactivity: Frog, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Hanson, M G Title Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. Citation The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71 PubMed Id 9736656 First Author Vicario-Abejón, C Title Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. Citation The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7256-71 PubMed Id 9736647 First Author Liou, J C Title Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures. Citation The Journal of Physiology; 503 ( Pt 1) pg129-39 PubMed Id 9288681
