Recombinant Human NT-4 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-04 Description: NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors, and promotes the survival of peripheral sensory sympathetic neurons. Recombinant Human NT-4 is a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues). Source: E.coli Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5) AA Sequence (monomer): GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Calculated Molecular Weight: 28.1 kDa Accession Number: P34130 Gene ID: 4909 crossreactivity: Frog, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Greer, P L Title The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Citation Cell; 140(5) pg704-16 PubMed Id 20211139 First Author Ghosh, D Title VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Citation Nature Communications; 7 pg10489 PubMed Id 26843440 First Author Vandewauw, I Title A TRP channel trio mediates acute noxious heat sensing. Citation Nature; 555(7698) pg662-666 PubMed Id 29539642
