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Growth Factors & Cytokines

Recombinant Human R-Spondin-1

Product Details

Catalog Number: 120-38
Description:

R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/β-catenin signaling pathway. Recombinant Human R-Spondin-1 is a 26.7 kDa protein consisting of 243 amino acid residues.  Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions.

Source: CHO cells

Synonyms: Roof plate-specific spondin-1, RSPO1

AA Sequence: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 is 1.0-3.0 μg/ml.

Calculated Molecular Weight: 26.7 kDa

Accession Number: Q2MKA7

Gene ID: 284654

Note:

1mg will be provided as 2x500μg.

Cross Reactivity Cited in References:
Country Of Origin: USA

Not for human use.

Research Interest

Product Reviews

Existing reviews
Perfect for organoid culture
My lung organoids grow well consistently even after passaging it couple of times and there were no  contamination issues.
From:  Eun Joo | Date:  7/8/2020
Good for organoid
This is good for my primary lung organoid culture.
From:  Jun | Date:  7/21/2020
High quality and good price
This product worked well for my project.  The price is reasonable and lower than most of vendors.
From:  Jin | Date:  8/26/2020