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Chemokines

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Recombinant Human SDF-1α (CXCL12)

Product Details

Catalog Number: 300-28A
Description:

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues.

Source: E.coli

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml.

Calculated Molecular Weight: 8 kDa

Accession Number: P48061

Gene ID: 6387

Cross Reactivity Cited in References:
Bacteria, Chicken, Cow, Dog, Hamster, Human, Human + Monkey, Human + Mouse, Human + Pig, Leech, Monkey, Mouse, Rat
Research Interest
AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing
References References
PubMed PubMed
SDS SDS
Product Line Product Line

Country Of Origin: USA

Not for human use.