Recombinant Human SDF-1α (CXCL12) 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-28A Description: SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues. Source: E.coli Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract IL-2-activated human T cells using a concentration range of 20.0-80.0 ng/ml. Calculated Molecular Weight: 8 kDa Accession Number: P48061 Gene ID: 6387 crossreactivity: Bacteria, Chicken, Cow, Dog, Hamster, Human, Human + Monkey, Human + Mouse, Human + Pig, Leech, Monkey, Mouse, Rat, Yeast References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Stanley, P Title Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. Citation The EMBO Journal; 27(1) pg62-75 PubMed Id 18079697 First Author Alekhina, O Title β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. Citation The Journal of Biological Chemistry; 291(50) pg26083-26097 PubMed Id 27789711 First Author Mandawat, A Title Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists. Citation Blood; 116(24) pg5306-15 PubMed Id 20810927 product.subtitle.productreviews Existing reviews Migration assay We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended. From: Jhomary | Date: 8/26/2020 × Migration assay We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended. From: Jhomary | Date: 8/26/2020 Close
