Recombinant Human sTRAIL/Apo2L

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Recombinant Human sTRAIL/Apo2L

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Product Details

Catalog Number: 310-04

Description:

TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic "death domain", which activates the cell's apoptotic machinery. The full length human TRAIL/Apo2L is a 281 amino acid protein, consisting of a 17 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 243 amino acid extracellular domain. Recombinant Human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF-homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.

Source: E.coli

Synonyms: TNF-Related Apoptosis-Inducing Ligand, TNFSF10, Apo2 Ligand, TL2

AA Sequence: MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1: Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED₅₀ for this effect is 1.0-3.0 ng/ml.

Assay #2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED₅₀ for this effect is 0.8 - 2.0 ng/ml.

Calculated Molecular Weight: 19.6 kDa

Accession Number: P50591

Gene ID: 8743

Cross Reactivity Cited in References:

Bacteria, Chicken, Mouse,

Research Interest

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

Fakler, M

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.

Blood; 113(8) pg1710-22

19 Feb 2009

19036706
Show Usages

Lundqvist, A

Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells.

Blood; 113(24) pg6120-7

11 Jun 2009

19202127
Show Usages

Tang, H

The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells.

BMC Biology; 9 pg18

19 Mar 2011

21418589
Show Usages

Maurer, G D

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.

BMC Cancer; 11 pg315

26 Jul 2011

21791085
Show Usages

Xie, Z

5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells.

BMC Cancer; 11 pg322

29 Jul 2011

21801359
Show Usages

Hotfilder, M

PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death.

British Journal of Cancer; 92(4) pg705-10

28 Feb 2005

15685229
Show Usages

Ashley, D M

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

British Journal of Cancer; 99(2) pg294-304

22 Jul 2008

18594532
Show Usages

Chen, Q

Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.

Cancer Cell; 20(4) pg538-49

18 Oct 2011

22014578
Show Usages

Vindrieux, D

Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis.

Cancer Cell International; 11 pg42

2 Dec 2011

22136382
Show Usages

Wei, J

Cytosine deaminase/5-fluorocytosine gene therapy and Apo2L/TRAIL cooperate to kill TRAIL-resistant tumor cells.

Cancer Gene Therapy; 14(7) pg640-51

0 Jul 2007

17479107
Show Usages

Hao, C

Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.

Cancer Research; 61(3) pg1162-70

1 Feb 2001

11221847
Show Usages

Jeffrey, I W

Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase.

Cancer Research; 62(8) pg2272-80

15 Apr 2002

11956083
Show Usages

Ehtesham, M

Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand.

Cancer Research; 62(24) pg7170-4

15 Dec 2002

12499252
Show Usages

Efimova, E

IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.

Cancer Research; 63(24) pg8768-76

15 Dec 2003

14695193
Show Usages

Fulda, S

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol.

Cancer Research; 64(1) pg337-46

1 Jan 2004

14729643
Show Usages

Hao, C

TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice.

Cancer Research; 64(23) pg8502-6

1 Dec 2004

15574753
Show Usages

Qiu, Y

The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.

Cancer Research; 67(10) pg4973-80

15 May 2007

17510428
Show Usages

Liu, X

The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.

Cancer Research; 67(10) pg4981-8

15 May 2007

17510429
Show Usages

Song, J H

Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells.

Cancer Research; 67(14) pg6946-55

15 Jul 2007

17638906
Show Usages

Hope, J

Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability.

Cell Death & Disease; 10(11) pg837

4 Nov 2019

31685811
Show Usages

Garnett, T O

Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis.

Cell Death and Differentiation; 13(11) pg1915-26

0 Nov 2006

16528386
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King, H A

Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.

Cell Death and Differentiation; 21(1) pg161-71

0 Jan 2014

24141718
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Carr, R M

Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.

Cell Death Discovery; 2 pg16067

0 2016

27648301
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Wang, M

Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway.

Cell Death Discovery; 5 pg153

10 Dec 2019

31839995
Show Usages

Wang, P

Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells.

Cellular Signalling; 19(11) pg2237-46

0 Nov 2007

17693058
Show Usages

Keogh, R J

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death.

Circulation Research; 100(6) pg834-41

30 Mar 2007

17322170
Show Usages

Saini, S

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocrine-Related Cancer; 26(6) pg551-563

1 Jun 2019

30999276
Show Usages

Dida, F

Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells.

Experimental Hematology; 36(10) pg1343-53

0 Oct 2008

18599181
Show Usages

Xu, L

Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts.

FEBS Letters; 583(5) pg943-8

4 Mar 2009

19223002
Show Usages

Szliszka, E

Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

International Journal of Molecular Sciences; 9(1) pg56-64

0 Jan 2008

19325719
Show Usages

Braunstein, I

Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation.

Journal of Biological Chemistry; 295(11) pg3590-3600

13 Mar 2020

32041780
Show Usages

Huang, D

STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death.

Journal of Biomedical Science; 19 pg35

30 Mar 2012

22462553
Show Usages

Lane, D

The prosurvival activity of ascites against TRAIL is associated with a shorter disease-free interval in patients with ovarian cancer.

Journal of Ovarian Research; 3 pg1

18 Jan 2010

20157422
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Lane, D

Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis.

Journal of Ovarian Research; 5(1) pg34

15 Nov 2012

23153223
Show Usages

Alladina, S J

TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2.

Journal of Vascular Research; 42(4) pg337-47

0 Jul 2005

15985761
Show Usages

Chen, S

Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.

Molecular Cancer; 9 pg23

29 Jan 2010

20113484
Show Usages

Jang, J

Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression.

Molecular Cancer; 9 pg262

28 Sep 2010

20875141
Show Usages

Fu, L

c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.

Molecular Cancer; 9 pg315

20 Dec 2010

21172010
Show Usages

Shiloh, R

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.

Nature Communications; 9(1) pg1759

1 May 2018

29717115
Show Usages

Fulda, S

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

Nature Medicine; 8(8) pg808-15

0 Aug 2002

12118245
Show Usages

Bürckstümmer, T

A reversible gene trap collection empowers haploid genetics in human cells.

Nature Methods; 10(10) pg965-71

0 Oct 2013

24161985
Show Usages

Bürckstümmer, T

A reversible gene trap collection empowers haploid genetics in human cells.

Nature Methods; 10(10) pg965-71

0 Oct 2013

24161985
Show Usages

Rokhlin, O W

Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP.

Oncogene; 24(45) pg6773-84

13 Oct 2005

16007156
Show Usages

Ito, K

Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway.

Oncogene; 25(30) pg4217-29

13 Jul 2006

16518414
Show Usages

Fulda, S

5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.

Oncogene; 25(37) pg5125-33

24 Aug 2006

16607283
Show Usages

Kilic, M

Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance.

Oncogene; 26(14) pg2027-38

29 Mar 2007

17043658
Show Usages

Grabarczyk, P

Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells.

Oncogene; 26(26) pg3797-810

31 May 2007

17173069
Show Usages

Goda, A E

Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.

Oncogene; 27(24) pg3435-45

29 May 2008

18193086
Show Usages

Toscano, F

P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells.

Oncogene; 27(30) pg4161-71

10 Jul 2008

18345033
Show Usages

Morioka, S

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP.

Oncogene; 28(23) pg2257-65

11 Jun 2009

19421137
Show Usages

Goncharenko-Khaider, N

The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells.

Oncogene; 29(40) pg5523-36

7 Oct 2010

20661217
Show Usages

Choi, J

Characterization of MUDENG, a novel anti-apoptotic protein.

Oncogenesis; 5 pge221

2 May 2016

27136675
Show Usages

Xu, J

Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells.

PLoS ONE; 5(4) pge10226

19 Apr 2010

20419107
Show Usages

Kauh, J

c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

PLoS ONE; 5(4) pge10376

28 Apr 2010

20442774
Show Usages

Furusawa, Y

DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines.

PLoS ONE; 7(1) pge29012

0 2012

22235259
Show Usages

Kong, R

Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.

PLoS ONE; 7(5) pge37222

0 2012

22666346
Show Usages

Zhang, S

Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells.

PLoS ONE; 7(12) pge51461

0 2012

23240027
Show Usages

Reuss, D E

Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.

PLoS ONE; 8(2) pge57152

0 2013

23437333
Show Usages

Turner, A

MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.

PLoS ONE; 8(2) pge56817

0 2013

23457619
Show Usages

Grabarczyk, P

Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation.

PLoS ONE; 5(9)

2 Sep 2010

20824091
Show Usages

Li, J

Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.

Scientific Reports; 5 pg9987

18 May 2015

25984950
Show Usages

Oh, Y

Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells.

Scientific Reports; 6 pg26803

25 May 2016

27222248
Show Usages

Zhou, W

Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells.

Scientific Reports; 6 pg28004

13 Jun 2016

27292433
Show Usages

Mohammadpour, H

Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-Î± activated adipose derived mesenchymal stem cells in breast cancer model.

Scientific Reports; 6 pg28433

22 Jun 2016

27329316
Show Usages

Chen, L

Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2Î± and inhibits tumor growth.

Scientific Reports; 6 pg32582

1 Sep 2016

27581364
Show Usages

Oh, Y

The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5.

Scientific Reports; 7(1) pg8027

14 Aug 2017

28808321
Show Usages

Nalli, A D

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs.

Scientific Reports; 8(1) pg17519

30 Nov 2018

30504817
Show Usages

Spano, C

Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer.

Scientific Reports; 9(1) pg1788

11 Feb 2019

30742129
Show Usages

Lee, S

Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis.

Scientific Reports; 9(1) pg13505

18 Sep 2019

31534206
Show Usages

Leaman, D W

Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis.

The Journal of Biological Chemistry; 277(32) pg28504-11

9 Aug 2002

12029096
Show Usages

Rokhlin, O W

Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription.

The Journal of Biological Chemistry; 277(36) pg33213-9

6 Sep 2002

12091392
Show Usages

Chawla-Sarkar, M

Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL.

The Journal of Biological Chemistry; 278(41) pg39461-9

10 Oct 2003

12881518
Show Usages

Morel, J

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt.

The Journal of Biological Chemistry; 280(16) pg15709-18

22 Apr 2005

15684417
Show Usages

Song, J H

Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

The Journal of Biological Chemistry; 280(13) pg12896-901

1 Apr 2005

15695523
Show Usages

Okhrimenko, H

Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis.

The Journal of Biological Chemistry; 280(25) pg23643-52

24 Jun 2005

15774464
Show Usages

Akasaki, Y

A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells.

The Journal of Biological Chemistry; 281(10) pg6165-74

10 Mar 2006

16319070
Show Usages

Colnaghi, R

Separating the anti-apoptotic and mitotic roles of survivin.

The Journal of Biological Chemistry; 281(44) pg33450-6

3 Nov 2006

16950794
Show Usages

Li, H

hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways.

The Journal of Biological Chemistry; 282(7) pg4943-50

16 Feb 2007

17178731
Show Usages

Mulherkar, N

MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.

The Journal of Biological Chemistry; 282(16) pg11715-21

20 Apr 2007

17314102
Show Usages

Song, J H

ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.

The Journal of Biological Chemistry; 283(36) pg25003-13

5 Sep 2008

18599488
Show Usages

Autefage, H

Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.

The Journal of Biological Chemistry; 284(17) pg11507-16

24 Apr 2009

19246452
Show Usages

Wang, C

Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.

The Journal of Biological Chemistry; 284(24) pg16183-90

12 Jun 2009

19376776
Show Usages

Thoh, M

Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.

The Journal of Biological Chemistry; 285(8) pg5888-95

19 Feb 2010

20018848
Show Usages

Sung, B

Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

The Journal of Biological Chemistry; 285(15) pg11498-507

9 Apr 2010

20154087
Show Usages

Qiu, J

Potentiation of tumor necrosis factor-alpha-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4.

The Journal of Biological Chemistry; 285(16) pg12241-7

16 Apr 2010

20177075
Show Usages

Sung, B

Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.

The Journal of Biological Chemistry; 285(46) pg35418-27

12 Nov 2010

20837473
Show Usages

Gupta, S C

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

The Journal of Biological Chemistry; 286(2) pg1134-46

14 Jan 2011

21078664
Show Usages

Prasad, S

Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.

The Journal of Biological Chemistry; 286(7) pg5546-57

18 Feb 2011

21156789
Show Usages

Le Goff, A

Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.

The Journal of Biological Chemistry; 287(42) pg35382-96

12 Oct 2012

22915589
Show Usages

Hong, S

Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.

The Journal of Biological Chemistry; 288(5) pg3560-70

1 Feb 2013

23255602
Show Usages

Gupta, S C

Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.

The Journal of Biological Chemistry; 288(45) pg32343-56

8 Nov 2013

24078627
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Xu, J

Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.

The Journal of Biological Chemistry; 288(46) pg33263-71

15 Nov 2013

24100030
Show Usages

Edagawa, M

Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib.

The Journal of Biological Chemistry; 289(31) pg21544-61

1 Aug 2014

24939851
Show Usages

Muñoz-Pinedo, C

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing.

The Journal of Biological Chemistry; 278(15) pg12759-68

11 Apr 2003

12556444
Show Usages

Muñoz-Pinedo, C

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing.

The Journal of Biological Chemistry; 278(15) pg12759-68

11 Apr 2003

12556444
Show Usages

Cheriyath, V

G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.

The Journal of Clinical Investigation; 117(10) pg3107-17

0 Oct 2007

17823654
Show Usages

Siegelin, M D

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells.

The Journal of Clinical Investigation; 121(4) pg1349-60

0 Apr 2011

21364280
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Sun, B

Response of bladder carcinoma cells to TRAIL and antisense oligonucleotide, Bcl-2 or clusterin treatments.

The Journal of Urology; 181(3) pg1361-71

0 Mar 2009

19157446
Show Usages

Chawla-Sarkar, M

IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis.

Journal of immunology (Baltimore, Md. : 1950); 169(2) pg847-55

15 Jul 2002

12097388
Show Usages

Akasaki, Y

Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma.

Journal of immunology (Baltimore, Md. : 1950); 173(7) pg4352-9

1 Oct 2004

15383564
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Sato, K

TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse.

Journal of immunology (Baltimore, Md. : 1950); 174(7) pg4025-33

1 Apr 2005

15778360
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Liang, X

Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax.

Journal of immunology (Baltimore, Md. : 1950); 178(1) pg503-10

1 Jan 2007

17182590
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Baritaki, S

Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation.

Journal of immunology (Baltimore, Md. : 1950); 179(8) pg5441-53

15 Oct 2007

17911631
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Baritaki, S

Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.

Journal of immunology (Baltimore, Md. : 1950); 180(9) pg6199-210

1 May 2008

18424742
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Jazirehi, A R

Histone deacetylase inhibitor sensitizes apoptosis-resistant melanomas to cytotoxic human T lymphocytes through regulation of TRAIL/DR5 pathway.

Journal of immunology (Baltimore, Md. : 1950); 192(8) pg3981-9

15 Apr 2014

24639349
Show Usages

Menon, L G

Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy.

Stem cells (Dayton, Ohio); 27(9) pg2320-30

0 Sep 2009

19544410
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Grisendi, G

Mesenchymal progenitors expressing TRAIL induce apoptosis in sarcomas.

Stem cells (Dayton, Ohio); 33(3) pg859-69

0 Mar 2015

25420617
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Fu, N Y

Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria.

Proceedings of the National Academy of Sciences of the United States of America; 104(24) pg10051-6

12 Jun 2007

17535899
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Agard, N J

Global kinetic analysis of proteolysis via quantitative targeted proteomics.

Proceedings of the National Academy of Sciences of the United States of America; 109(6) pg1913-8

7 Feb 2012

22308409
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Koh, D

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

Proceedings of the National Academy of Sciences of the United States of America; 111(42) pg15078-83

21 Oct 2014

25288747
Show Usages

Song, J H

Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research; 9(11) pg4255-66

15 Sep 2003

14519653
Show Usages

Runnebaum, I B

Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2.

Clinical cancer research : an official journal of the American Association for Cancer Research; 11(17) pg6325-32

1 Sep 2005

16144937
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Zou, W

Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research; 12(1) pg273-80

1 Jan 2006

16397052
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Li, Y

Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research; 12(9) pg2716-29

1 May 2006

16675563
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David, E

Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors.

Clinical cancer research : an official journal of the American Association for Cancer Research; 14(16) pg5090-8

15 Aug 2008

18698026
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Elias, A

Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research; 15(17) pg5457-65

1 Sep 2009

19706813
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Roth, P

SC68896, a novel small molecule proteasome inhibitor, exerts antiglioma activity in vitro and in vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research; 15(21) pg6609-18

1 Nov 2009

19825946
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Brüning, A

Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research; 11(12) pg4316-20

15 Jun 2005

15958612
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Brüning, A

Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research; 11(12) pg4316-20

15 Jun 2005

15958612
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Dolcet, X

FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis.

Laboratory investigation; a journal of technical methods and pathology; 85(7) pg885-94

0 Jul 2005

15864316
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Chakravarti, A

Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro.

Laboratory investigation; a journal of technical methods and pathology; 88(2) pg171-84

0 Feb 2008

18040268
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Johnson, A L

Tumor necrosis factor-related apoptosis inducing ligand expression and activity in hen granulosa cells.

Reproduction (Cambridge, England); 133(3) pg609-16

0 Mar 2007

17379655
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Szliszka, E

Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells.

Evidence-based complementary and alternative medicine : eCAM; 2011 pg535172

0 2011

19892808
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Hsieh, Y

Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3.

Cell death & disease; 3 pge347

12 Jul 2012

22785533
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Grunert, M

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-ÎºB by TRAIL.

Cell death & disease; 3 pge414

25 Oct 2012

23096115
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Matthews, G M

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma.

Cell death & disease; 4 pge798

12 Sep 2013

24030150
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Ma, H

Transcriptome analysis of glioma cells for the dynamic response to Î³-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas.

Cell death & disease; 4 pge895

31 Oct 2013

24176853
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Teng, Y

Inhibition of eIF2Î± dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells.

Cell death & disease; 5 pge1060

13 Feb 2014

24525736
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Henrich, C J

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.

Cell death & disease; 6 pge1666

26 Feb 2015

25719250
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Fauster, A

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

Cell death & disease; 6 pge1767

21 May 2015

25996294
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Miles, M A

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.

Cell death & disease; 8(10) pge3062

5 Oct 2017

28981092
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Elia, A

Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL.

Cell death & disease; 8(12) pg3204

12 Dec 2017

29233971
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Delannoy, A

BIM and NOXA are mitochondrial effectors of TAF6Î´-driven apoptosis.

Cell death & disease; 9(2) pg70

22 Jan 2018

29358700
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Zhang, N

Glycogen synthase kinase-3Î² inhibition promotes lysosome-dependent degradation of c-FLIP

Cell death & disease; 9(2) pg230

14 Feb 2018

29445085
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Yulis, M

Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.

Cell death & disease; 9(3) pg389

9 Mar 2018

29523777
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Legler, K

The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells.

Cell death & disease; 9(5) pg445

1 May 2018

29670075
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Lincoln, F A

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism.

Cell death & disease; 9(11) pg1112

1 Nov 2018

30385739
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Zhu, Z

Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.

Cell death & disease; 10(2) pg118

11 Feb 2019

30742128
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Deveaux, W

Defining rules for cancer cell proliferation in TRAIL stimulation.

NPJ systems biology and applications; 5 pg5

0 2019

30792889
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Norian, L A

[Not Available].

Journal of oncology; 2009 pg408038

0 2009

19547714
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Fan, S

The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation.

Neoplasia (New York, N.Y.); 12(4) pg346-56

0 Apr 2010

20360945
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Growth Factors & Cytokines