Recombinant Human TL-1A 0 ReviewsSubmit a Review Product Details Catalogue Number: 310-23 Description: TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in the placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF-κB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant Human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues. Source: E.coli Synonyms: TNFSF15, VEGI AA Sequence: QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate IFN-γ production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Note: Results may vary with PBMC donors. Calculated Molecular Weight: 22 kDa Accession Number: O95150 Gene ID: 9966 Note: 1mg will be provided as 2x500μg. crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Immune System TNF Superfamily product.subtitle.recentcitations First Author Li, J Title Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. Citation Nature Communications; 10(1) pg3371 PubMed Id 31358760 First Author Hedl, M Title A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1. Citation Proceedings of the National Academy of Sciences of the United States of America; 111(37) pg13451-6 PubMed Id 25197060 First Author McLaren, J E Title The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Citation Journal of immunology (Baltimore, Md. : 1950); 184(10) pg5827-34 PubMed Id 20410491
