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Growth Factors & Cytokines

Recombinant Human VEGF121

Product Details

Catalog Number: 100-20A
Description:

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

Source: E.coli

Synonyms: Vascular Endothelial Growth Factor 121, VPF, VEGF-A

AA Sequence (monomer): APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.

Calculated Molecular Weight: 28.4 kDa

Accession Number: P15692

Gene ID: 7422

Cross Reactivity Cited in References:
Country Of Origin: USA

Not for human use.

Research Interest

Product Reviews

Existing reviews
high quality product for vascular biology research
We use this product in our project for more than 5 years, by which the hiPSC-derived vascular endothelial cell were differentiated
From:  Ping | Date:  8/26/2020