Recombinant Human/Murine FGF-8b

Product Details

Catalog Number: 100-25

Description:

FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-8, FGF-8b, AIGF, HBGF-8

AA Sequence: MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED₅₀ is ≤ 5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁵ units/mg.

Calculated Molecular Weight: 22.5 kDa

Accession Number: P55075

Gene ID: 2253

Note:

1mg will be provided as 2x500μg

Cross Reactivity Cited in References:

Chicken, Hamster, Human, Mouse, Rabbit, Rat

Research Interest

Angiogenesis/Cardiovascular

Bone, Skeletal, Cartilage

Stem Cells & Differentiation

Country Of Origin: USA

Not for human use.

Growth Factors & Cytokines