Recombinant Human/Murine FGF-8b 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-25 Description: FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-8, FGF-8b, AIGF, HBGF-8 AA Sequence: MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 5 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg. Calculated Molecular Weight: 22.5 kDa Accession Number: P55075 Gene ID: 2253 Note: 1mg will be provided as 2x500μg crossreactivity: Chicken, Hamster, Human, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Zhang, X Title Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Citation The Journal of Biological Chemistry; 281(23) pg15694-700 PubMed Id 16597617 First Author Lund, C Title Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells. Citation Stem Cell Reports; 7(2) pg149-57 PubMed Id 27426041 First Author Loo, B Title Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b. Citation The Journal of Biological Chemistry; 277(36) pg32616-23 PubMed Id 12077148
