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Growth Factors & Cytokines

Recombinant Human/Murine/Rat Activin A (CHO derived)

Product Details

Catalog Number: 120-14P

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Source: CHO cells

Synonyms: Inhibin beta-1, FRP, FSH (Follicle-Stimulating Hormone)-releasing protein, Erythroid Differentiation Factor (EDF)


Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 26 kDa

Accession Number: P08476

Gene ID: 3624


1mg will be provided as 2x500μg.

Cross Reactivity Cited in References:
Country Of Origin: USA

Not for human use.

Research Interest

Product Reviews

Existing reviews
Great for definitive endoderm--reliable and reproducible!
I use this activin A for the definitive endoderm stages of my human iPSC differentiations. This component of their media is pretty critical, and I have had reproducible success getting cells through this phase using Peprotech. Other labs differentiating stem cells have had similar success. This product will be a repeat order for me!
From:  Kendall | Date:  8/26/2020