Recombinant Human/Murine/Rat BMP-2 (E.coli derived) 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-02 Description: BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate, ovary, and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. Source: E.coli Synonyms: Bone Morphogenetic Protein-2, BMP-2A AA Sequence (monomer): MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml. Calculated Molecular Weight: 26 kDa Accession Number: P12643 Gene ID: 650 crossreactivity: Alpaca, Cow, Dog, Gelatin Microparticles, Human, Monkey, Mouse, Rabbit, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Remšík, J Title TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells Citation Scientific Reports; 10(1) pg11396 PubMed Id 32647280 First Author Abu-Bonsrah, K D Title Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells. Citation Stem Cell Reports; 10(1) pg134-150 PubMed Id 29233551 First Author Dupont, S Title FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Citation Cell; 136(1) pg123-35 PubMed Id 19135894