Growth Factors & Cytokines

Recombinant Murine Amphiregulin

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 315-36
Description:

Amphiregulin is an EGF-related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Murine Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.

Source: E.coli

Synonyms: AR, AREG, Colorectum cell-derived growth factor (CRDGF)

AA Sequence: SVRVEQVIKP KKNKTEGEKS TEKPKRKKKG GKNGKGRRNK KKKNPCTAKF QNFCIHGECR YIENLEVVTC NCHQDYFGER CGEKSMKTHS EDDKDLSK

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.

Calculated Molecular Weight: 11.5 kDa

Accession Number: P31955

Gene ID: 11839

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Pasciuto, E
Title
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Citation
Cell; 182(3) pg625-640.e24
PubMed Id
First Author
Lindzen, M
Title
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53
Citation
Oncogene; 40(21) pg3665-3679
PubMed Id