Recombinant Murine Flt3-Ligand 1 ReviewsSubmit a Review Product Details Catalogue Number: 250-31L Description: Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand has no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Murine Flt3-Ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues. Source: E.coli Synonyms: Fms-related tyrosine kinase 3 ligand, FltL AA Sequence: MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 5.0 – 8.0 ng/ml. Calculated Molecular Weight: 18.6 kDa Accession Number: P49772 Gene ID: 14256 crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Cell Culture Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author Kauts, M Title Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. Citation Stem Cell Reports; 11(4) pg1009-1020 PubMed Id 30197119 First Author Guo, S Title Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Citation Proceedings of the National Academy of Sciences of the United States of America; 109(41) pg16636-41 PubMed Id 23012470 First Author Zhao, L Title KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice. Citation Blood; 119(6) pg1511-21 PubMed Id 22160378 product.subtitle.productreviews Existing reviews Recombinant Murin Flt3-Ligand We use this product in our murine media. Upon arrival we make stock dilutions. They keep well in -20 until we are ready to prep more media From: Nichole | Date: 8/26/2020 × Recombinant Murin Flt3-Ligand We use this product in our murine media. Upon arrival we make stock dilutions. They keep well in -20 until we are ready to prep more media From: Nichole | Date: 8/26/2020 Close