Growth Factors & Cytokines

Recombinant Murine GM-CSF

Product Details

Catalogue Number: 315-03
Description:
Recombinant Murine GM-CSF

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues.

Source: E.coli

Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α

AA Sequence: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 14.2 kDa

Accession Number: P01587

Gene ID: 12981

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Li, Y
Title
Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis.
Citation
Molecular Oncology; 16(15) pg2861-2880
PubMed Id
First Author
Hooper, K M
Title
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy.
Citation
The Journal of Cell Biology; 221(6)
PubMed Id
First Author
Diethelm, P
Title
LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response.
Citation
European Journal of Immunology; 52(6) pg924-935
PubMed Id

product.subtitle.productreviews

Existing reviews
Excellent product
We have been using this product for 2 yrs for Bone marrow derived dendritic cell experiments and I never disappointed with the results. I highly recommend this product to our collaborators.
From:  Chetan | Date:  7/8/2020
Great product
This cytokine was used to stimulate various immune cells extracted from spleen and bone marrow of mice for the past few years with great performance.
From:  Jin | Date:  7/21/2020
mGMCSF
Great for deriving DCs from BM.
From:  Kevin | Date:  8/26/2020
BMDCs
we used this product for BMDCs in vitro maduration.
From:  Aitziber | Date:  8/26/2020