Growth Factors & Cytokines

Recombinant Murine IGF-I

Product Details

Catalogue Number: 250-19
Description:

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro.  IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.  The IGFs belong to the Insulin gene family, which also contains insulin and relaxin.  The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.  IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.  Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.  Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.  Recombinant Murine IGF-I is a 7.6 kDa globular protein containing amino acids including 3 intra-molecular disulfide bonds.

Source: E.coli

Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA

AA Sequence: GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 7.6 kDa

Accession Number: P05017

Gene ID: 16000

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Dignum, T
Title
Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.
Citation
Cell Reports; 36(11) pg109675
PubMed Id
First Author
Dowery, R
Title
Peripheral B cells repress B-cell regeneration in aging through a TNF-α/IGFBP-1/IGF-1 immune-endocrine axis.
Citation
Blood; 138(19) pg1817-1829
PubMed Id
First Author
Rore, H
Title
Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
Citation
Communications Biology; 4(1) pg802
PubMed Id