Recombinant Murine IL-11 0 ReviewsSubmit a Review Product Details Catalogue Number: 220-11 Description: IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Murine IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues. Source: E.coli Synonyms: AGIF (Adipogenesis inhibitory factor) AA Sequence: MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 19.1 kDa Accession Number: P47873 Gene ID: 16156 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Cova, G Title Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. Citation The Journal of Experimental Medicine; 218(10) PubMed Id 34459852 First Author Ho, T T Title Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions. Citation The Journal of Experimental Medicine; 218(7) PubMed Id 34032859 First Author Numata, A Title Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Citation Blood; 136(15) pg1735-1747 PubMed Id 32542325
