Recombinant Murine IL-2 4 ReviewsSubmit a Review Product Details Catalogue Number: 212-12 Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues. Source: E.coli Synonyms: T-cell growth factor (TCGF), Aldesleukin AA Sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 17.2 kDa Accession Number: P04351 Gene ID: 16183 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Mouse, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Ashby, J F Title Microfluidic T Cell Selection by Cellular Avidity. Citation Advanced Healthcare Materials; 11(16) pge2200169 PubMed Id 35657072 First Author Chang, J Title ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation. Citation Journal of immunology (Baltimore, Md. : 1950); 209(2) pg301-309 PubMed Id 35760518 First Author Kalbasi, A Title Potentiating adoptive cell therapy using synthetic IL-9 receptors. Citation Nature; 607(7918) pg360-365 PubMed Id 35676488 product.subtitle.productreviews Existing reviews Product with great consistency We have been using this cytokine for splenic T cells in numerous publications for the past 10 years. Great consistency! From: Jin | Date: 7/21/2020 × Product with great consistency We have been using this cytokine for splenic T cells in numerous publications for the past 10 years. Great consistency! From: Jin | Date: 7/21/2020 Close Reliable product Our lab has been using Peprotech cytokines for many years because of its quality and reliability. Would highly recommend for assays in which murine T cells, splenocytes, or T cell clones need to be grown and stimulated. From: Diane | Date: 8/26/2020 × Reliable product Our lab has been using Peprotech cytokines for many years because of its quality and reliability. Would highly recommend for assays in which murine T cells, splenocytes, or T cell clones need to be grown and stimulated. From: Diane | Date: 8/26/2020 Close For in vitro NKs expansion We used this product for in vitro NKs expansion From: Aitziber | Date: 8/26/2020 × For in vitro NKs expansion We used this product for in vitro NKs expansion From: Aitziber | Date: 8/26/2020 Close Great consistent mouse recombinant IL-2 We have been using this recombinant mouse IL-2 for almost 20 years now in the lab. Our T cell cultures grow and expand very well with IL-2. From: Chirag | Date: 8/31/2020 × Great consistent mouse recombinant IL-2 We have been using this recombinant mouse IL-2 for almost 20 years now in the lab. Our T cell cultures grow and expand very well with IL-2. From: Chirag | Date: 8/31/2020 Close
