Recombinant Murine IL-2 4 ReviewsSubmit a Review Product Details Catalogue Number: 212-12 Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues. Source: E.coli Synonyms: T-cell growth factor (TCGF), Aldesleukin AA Sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 17.2 kDa Accession Number: P04351 Gene ID: 16183 crossreactivity: Human, Human + Mouse, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Yarmus, M Title Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Citation Proceedings of the National Academy of Sciences of the United States of America; 103(19) pg7384-9 PubMed Id 16651517 First Author Dupont, M S Title Host genetic control of natural killer cell diversity revealed in the Collaborative Cross. Citation Proceedings of the National Academy of Sciences of the United States of America; 118(10) PubMed Id 33649222 First Author Suto, A Title Development and characterization of IL-21-producing CD4+ T cells. Citation The Journal of Experimental Medicine; 205(6) pg1369-79 PubMed Id 18474630 product.subtitle.productreviews Existing reviews Product with great consistency We have been using this cytokine for splenic T cells in numerous publications for the past 10 years. Great consistency! From: Jin | Date: 7/21/2020 × Product with great consistency We have been using this cytokine for splenic T cells in numerous publications for the past 10 years. Great consistency! From: Jin | Date: 7/21/2020 Close Reliable product Our lab has been using Peprotech cytokines for many years because of its quality and reliability. Would highly recommend for assays in which murine T cells, splenocytes, or T cell clones need to be grown and stimulated. From: Diane | Date: 8/26/2020 × Reliable product Our lab has been using Peprotech cytokines for many years because of its quality and reliability. Would highly recommend for assays in which murine T cells, splenocytes, or T cell clones need to be grown and stimulated. From: Diane | Date: 8/26/2020 Close For in vitro NKs expansion We used this product for in vitro NKs expansion From: Aitziber | Date: 8/26/2020 × For in vitro NKs expansion We used this product for in vitro NKs expansion From: Aitziber | Date: 8/26/2020 Close Great consistent mouse recombinant IL-2 We have been using this recombinant mouse IL-2 for almost 20 years now in the lab. Our T cell cultures grow and expand very well with IL-2. From: Chirag | Date: 8/31/2020 × Great consistent mouse recombinant IL-2 We have been using this recombinant mouse IL-2 for almost 20 years now in the lab. Our T cell cultures grow and expand very well with IL-2. From: Chirag | Date: 8/31/2020 Close
