Animal-Free Recombinant Murine IL-2 1 ReviewsSubmit a Review Product Details Catalog Number: AF-212-12 Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: T-cell growth factor, (TCGF), Aldesleukin AA Sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 17.2 kDa Accession Number: P04351 Gene ID: 16183 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation Recent Citations First Author Fiancette, R Title Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity Citation Nature Immunology; 22(10) pg1245-1255 PubMed ID 34556884 First Author Cardoso, F Title Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit Citation Nature; 597(7876) pg410-414 PubMed ID 34408322 First Author Cui, J Title IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. Citation Cell Death & Disease; 12(6) pg501 PubMed ID 34006836 Product Reviews Existing reviews Best cytokine of its kind Have used this cytokine for T cell expansion. Very reliable and efficient. Gives good results every time. From: Vineet | Date: 8/26/2020 × Best cytokine of its kind Have used this cytokine for T cell expansion. Very reliable and efficient. Gives good results every time. From: Vineet | Date: 8/26/2020 Close
