Growth Factors & Cytokines

Recombinant Murine IL-5

Product Details

Catalogue Number: 215-15
Description:

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

Source: E.coli

Synonyms: EDF, BCDFII, TRF

AA Sequence: MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 26.2 kDa

Accession Number: P04401

Gene ID: 16191

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wigton, E J
Title
MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
Citation
The Journal of Experimental Medicine; 218(11)
PubMed Id
First Author
de Lucía Finkel, P
Title
Serum free culture for the expansion and study of type 2 innate lymphoid cells
Citation
Scientific Reports; 11(1) pg12233
PubMed Id
First Author
Karcz, T P
Title
UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.
Citation
The Journal of Clinical Investigation; 131(7)
PubMed Id