Recombinant Murine Leptin 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-31 Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. Calculated Molecular Weight: 16.2 kDa Accession Number: P41160 Gene ID: 16846 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Hamster, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author Porniece Kumar, M Title Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Citation Nature Metabolism; 3(12) pg1662-1679 PubMed Id 34931084 First Author Heiss, C N Title The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism. Citation Cell Reports; 35(8) pg109163 PubMed Id 34038733 First Author Takenaga, K Title Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice. Citation Scientific Reports; 11(1) pg2923 PubMed Id 33536560
