Recombinant Murine Leptin 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-31 Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. Calculated Molecular Weight: 16.2 kDa Accession Number: P41160 Gene ID: 16846 crossreactivity: Hamster, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author Zhang, L Title Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling. Citation Nature Communications; 9(1) pg4722 PubMed Id 30413707 First Author Shiuchi, T Title Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β Citation Scientific Reports; 7(1) pg15141 PubMed Id 29123236 First Author Hong, C Title ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. Citation PLoS ONE; 5(12) pge15333 PubMed Id 21151569
