Recombinant Murine Leptin 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-31 Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. Calculated Molecular Weight: 16.2 kDa Accession Number: P41160 Gene ID: 16846 crossreactivity: Hamster, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author McCowen, K C Title Leptin signaling in the hypothalamus of normal rats in vivo. Citation Endocrinology; 139(11) pg4442-7 PubMed Id 9794450 First Author Lord, G M Title Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Citation Nature; 394(6696) pg897-901 PubMed Id 9732873 First Author Igel, M Title Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. Citation Endocrinology; 138(10) pg4234-9 PubMed Id 9322935
