Recombinant Murine LIX (CXCL6) (92 a.a.)

Product Details

Catalogue Number: 250-17

Description:

CXCL6, also known as LIX in mice, is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX, LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokines that binds to the CXCR1 and CXCR2 receptors. Recombinant Murine LIX is a 9.8 kDa protein containing 92 amino acid residues.

Source: E.coli

Synonyms: CXCL6, GCP-2 (human), Granulocyte Chemotactic Protein-2

AA Sequence: APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIQKI LGSDKKKAKR NALAVERTAS VQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 9.8 kDa

Accession Number: P50228

Gene ID: 20311

crossreactivity:

Human, Mouse

Country Of Origin: USA

Not for human use.

Research Interest

Angiogenesis/Cardiovascular

Bone, Skeletal, Cartilage

product.subtitle.recentcitations

First Author

Van den Steen, P E

Title

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.

Citation

The Journal of Biological Chemistry; 281(27) pg18626-37

PubMed Id

16672230

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Ueda, Y

Title

Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.

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The Journal of Experimental Medicine; 201(11) pg1771-80

PubMed Id

15939792

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Singh, K

Title

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PubMed Id

28655871

Chemokines