Recombinant Murine MCP-5 (CCL12)

Product Details

Catalogue Number: 250-04

Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine MCP-5 is a 9.3 kDa protein containing 82 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-5, CCL12

AA Sequence: GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTILDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.

Calculated Molecular Weight: 9.3 kDa

Accession Number: Q62401

Gene ID: 20293

crossreactivity:

Bacteria, Human, Mouse

Country Of Origin: USA

Not for human use.

Research Interest

Angiogenesis/Cardiovascular

product.subtitle.recentcitations

First Author

Sawada, S

Title

Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors.

Citation

The Journal of Experimental Medicine; 187(9) pg1439-49

PubMed Id

9565636

First Author

Sarafi, M N

Title

Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1.

Citation

The Journal of Experimental Medicine; 185(1) pg99-109

PubMed Id

8996246

First Author

Hansell, C A

Title

The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.

Citation

Journal of immunology (Baltimore, Md. : 1950); 201(8) pg2510-2519

PubMed Id

30158126

Chemokines