Recombinant Murine MIP-1β (CCL4) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-32 Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1β, CCL4, ACT-2 AA Sequence: APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 20.0-100.0 ng/ml. Calculated Molecular Weight: 7.8 kDa Accession Number: P14097 Gene ID: 20303 crossreactivity: Hamster, Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Wound Healing Transplantation product.subtitle.recentcitations First Author He, H Title Aging-induced IL27Ra signaling impairs hematopoietic stem cells. Citation Blood; 136(2) pg183-198 PubMed Id 32305041 First Author Liou, G Title Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs. Citation The Journal of Cell Biology; 202(3) pg563-77 PubMed Id 23918941 First Author McGarvey, A C Title A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation. Citation The Journal of Experimental Medicine; 214(12) pg3731-3751 PubMed Id 29093060