Chemokines

Recombinant Murine MIP-3β (CCL19)

Product Details

Catalogue Number: 250-27B
Description:

MIP-3β is a CC chemokine, expressed in the thymus, lymph nodes, and in activated bone marrow stromal cells that signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes, and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant Murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: Macrophage Inflammatory Protein-3β, CCL19, ELC, Exodus-3, SCYA19

AA Sequence: GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract activated human T cells expressing the CCR7 receptor. The ED50 for this effect is 30-90 ng/ml.

Calculated Molecular Weight: 9.2 kDa

Accession Number: O70460

Gene ID: 24047

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Reijmers, R M
Title
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.
Citation
Blood; 117(23) pg6162-71
PubMed Id
First Author
López-Cotarelo, P
Title
A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
Citation
The Journal of Biological Chemistry; 290(2) pg827-40
PubMed Id
First Author
Pabbisetty, S K
Title
Peripheral tolerance can be modified by altering KLF2-regulated Treg migration.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 113(32) pgE4662-70
PubMed Id

product.subtitle.productreviews

Existing reviews
migration assays
works well for dendritic cells in migration assays!
From:  Caitlin | Date:  7/13/2020