Growth Factors & Cytokines

Recombinant Murine Noggin

Product Details

Catalogue Number: 250-38
Description:

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors.  Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures.  Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14.  Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system.  Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.  Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.

Source: E.coli

Synonyms: None

AA Sequence (monomer): MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin.

Calculated Molecular Weight: 46.4 kDa

Accession Number: P97466

Gene ID: 18121

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lai, N
Title
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Citation
ACR Open Rheumatology; 180(1) pg33-49.e22
PubMed Id
First Author
Fellows, R
Title
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Citation
Nature Communications; 9(1) pg105
PubMed Id
First Author
Nanki, K
Title
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Citation
Cell; 174(4) pg856-869.e17
PubMed Id

product.subtitle.productreviews

Existing reviews
organoids
Works perfect with both human and murine pancreatic organoids.
From:  Mitesh | Date:  7/9/2020
Murine Noggin for CRC and pan Organoid Culture
Murine Noggin I am using for Human as well as mouse Pancreas, Colon and Rectal Organoid culture medias.
Consistent activity each lot and next day delivery.
From:  Hardik | Date:  8/14/2020
mNoggin for organoids culture
We have used it for both mouse and human pancreatic organoids and it works perfectly!
From:  Pilar | Date:  8/27/2020