Growth Factors & Cytokines

Recombinant Murine PDGF-BB

Product Details

Catalogue Number: 315-18
Description:

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two β chains (218 total amino acids).

Source: E.coli

Synonyms: Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)

AA Sequence (monomer): SLGSLAAAEP AVIAECKTRT EVFQISRNLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RASQVQMRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TIVTPRPVT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 ng/ml.

Calculated Molecular Weight: 24.4 kDa

Accession Number: P31240

Gene ID: 18591

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Mukai, H
Title
PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
Citation
Scientific Reports; 6 pg18979
PubMed Id
First Author
Zhou, X
Title
Circuit Design Features of a Stable Two-Cell System.
Citation
Cell; 172(4) pg744-757.e17
PubMed Id
First Author
Nguyen, T T
Title
PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 113(36) pg10091-6
PubMed Id

product.subtitle.productreviews

Existing reviews
Good!
Worked as described!
From:  Lillian | Date:  7/21/2020