Recombinant Murine TRAIL 0 ReviewsSubmit a Review Product Details Catalog Number: 315-19 Description: TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant Murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF-homologous portion of the extracellular domain of the full length TRAIL protein. Source: E.coli Synonyms: TNF-Related Apoptosis-Inducing Ligand, TNFSF10, TL2 AA Sequence: MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml. Assay #2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40.0-60.0 ng/ml. Calculated Molecular Weight: 20 kDa Accession Number: P50592 Gene ID: 22035 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Cancer Immune System TNF Superfamily Recent Citations First Author Liao, H Title TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment. Citation Cell Death & Disease; 10(2) pg77 PubMed ID 30692521 First Author Kattah, M G Title A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. Citation The Journal of Experimental Medicine; 215(7) pg1839-1852 PubMed ID 29930103 First Author Nam, G Title Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer. Citation Nature Communications; 9(1) pg2165 PubMed ID 29867097
