Growth Factors & Cytokines

Recombinant Rat IL-10

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Product Details

Catalogue Number: 400-19
Description:


Recombinant Rat IL-10

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes.  IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α.  Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions.  Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells.  Recombinant Rat IL-10 is an 18.7 kDa protein of 160 amino acid residues.

Source: E.coli

Synonyms: B-TCGF, CSIF, TGIF

AA Sequence: SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is ≤10ng/ml.

Calculated Molecular Weight: 18.7 kDa

Accession Number: P29456

Gene ID: 25325

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Bourdonnay, E
Title
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
Citation
The Journal of Experimental Medicine; 212(5) pg729-42
PubMed Id
First Author
Chen, H
Title
IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway.
Citation
Scientific Reports; 6 pg30459
PubMed Id
First Author
Schneider, D J
Title
Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication.
Citation
The Journal of Biological Chemistry; 292(51) pg20897-20910
PubMed Id