Chemokines

Recombinant Rat MIP-1α (CCL3)

Product Details

Catalogue Number: 400-15
Description:

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Rat MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: Macrophage Inflammatory Protein-1α, CCL3, LD78α

AA Sequence: APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1:  Determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0-100.0 ng/ml.

Assay #2:  Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P50229

Gene ID: 25542

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Rius, C
Title
Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 185(6) pg3718-27
PubMed Id
First Author
Abu-Taha, M
Title
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
Citation
Journal of immunology (Baltimore, Md. : 1950); 183(2) pg1393-402
PubMed Id
First Author
Altomonte, J
Title
Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells.
Citation
Cancer Gene Therapy; 16(3) pg266-78
PubMed Id