Chemokines

Recombinant Rat RANTES (CCL5)

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Product Details

Catalogue Number: 400-13
Description:


Recombinant Rat RANTES (CCL5)

RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Rat RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta

AA Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1:  Determined by its ability to chemoattract rat peritoneal macrophages using a concentration range of 50.0-100.0 ng/ml.

Assay #2:  Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: P50231

Gene ID: 81780

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Mateo, T
Title
A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.
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Blood; 110(6) pg1895-902
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Yan, S R
Title
Differential pattern of inflammatory molecule regulation in intestinal epithelial cells stimulated with IL-1.
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Journal of immunology (Baltimore, Md. : 1950); 177(8) pg5604-11
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Abu-Taha, M
Title
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
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Journal of immunology (Baltimore, Md. : 1950); 183(2) pg1393-402
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