Recombinant Human Apo-SAA 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-13 Description: Human Apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human Apo-SAA1α, except for the presence of an N-terminal methionine, the substitution of asparagine for aspartic acid at position 60, and arginine for histidine at position 71 (the latter two substituted residues are present in Apo-SAA2β). The calculated molecular weight of Recombinant Human Apo-SAA is 11.7 kDa. Source: E.coli Synonyms: Serum amyloid A protein (SAA), Serum amyloid A apolipoprotein, Amyloid fibril protein AA, TP53I4, PIG4 AA Sequence: MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS NARENIQRFF GRGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 μM.* * Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13 Calculated Molecular Weight: 11.7 kDa Accession Number: P0DJI8 Gene ID: 6288 crossreactivity: Bacteria, Hamster, Human, Human + Mouse, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Li, W Title Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases. Citation Scientific Reports; 8(1) pg166 PubMed Id 29317708 First Author He, R L Title Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. Citation Blood; 113(2) pg429-37 PubMed Id 18952897 First Author Lu, J Title Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis. Citation Proceedings of the National Academy of Sciences of the United States of America; 111(14) pg5189-94 PubMed Id 24706838
