Recombinant Human Apo-SAA 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-13 Description: Human Apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human Apo-SAA1α, except for the presence of an N-terminal methionine, the substitution of asparagine for aspartic acid at position 60, and arginine for histidine at position 71 (the latter two substituted residues are present in Apo-SAA2β). The calculated molecular weight of Recombinant Human Apo-SAA is 11.7 kDa. Source: E.coli Synonyms: Serum amyloid A protein (SAA), Serum amyloid A apolipoprotein, Amyloid fibril protein AA, TP53I4, PIG4 AA Sequence: MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS NARENIQRFF GRGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 μM.* * Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13 Calculated Molecular Weight: 11.7 kDa Accession Number: P0DJI8 Gene ID: 6288 crossreactivity: Bacteria, Hamster, Human, Human + Mouse, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Yu, S Title Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification. Citation The FEBS Journal; 288(10) pg3186-3196 PubMed Id 33145969 First Author Christophersen, D V Title Accelerated atherosclerosis caused by serum amyloid A response in lungs of ApoE-/- mice. Citation FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 35(3) pge21307 PubMed Id 33638910 First Author Nurmi, K Title Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages. Citation Clinical & translational immunology; 10(8) pge1323 PubMed Id 34377468
