Chemokines

Recombinant Human BCA-1 (CXCL13)

Product Details

Catalogue Number: 300-47
Description:

BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor, CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes, and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant Human BCA-1 is a 10.3 kDa protein containing 87 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand

AA Sequence: VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 10.3 kDa

Accession Number: O43927

Gene ID: 10563

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Le Roux, D
Title
Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells.
Citation
Blood; 119(1) pg95-105
PubMed Id
First Author
Chao, M P
Title
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy.
Citation
Blood; 118(18) pg4890-901
PubMed Id
First Author
Trinidad, E M
Title
An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.
Citation
Blood; 114(24) pg5081-90
PubMed Id

product.subtitle.productreviews

Existing reviews
For migration assay
We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended.
From:  Jhomary | Date:  26/08/2020