Growth Factors & Cytokines

Recombinant Human BMP-4 (E.coli derived)

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Product Details

Catalogue Number: 120-05ET
Description:
Recombinant Human BMP-4 (E.coli derived)

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.  The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa.

Source: E.coli

Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4

AA Sequence (monomer): KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.

Calculated Molecular Weight: 23.9 kDa

Accession Number: P12644

Gene ID: 652

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Jacobo Lopez, A
Title
Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells.
Citation
Cell Proliferation; 55(4) pge13198
PubMed Id
First Author
Aykul, S
Title
BMP-4 Extraction from Extracellular Matrix and Analysis of Heparin-Binding Properties.
Citation
Molecular Biotechnology; 64(2) pg156-170
PubMed Id
First Author
Frey, P
Title
SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.
Citation
Oncogene; 41(6) pg824-837
PubMed Id