Recombinant Human CDNF 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 450-05 Descripcion CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine-specific neurons. CDNF and its structural homolog, MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human CDNF is an 18.5 kDa protein consisting of 162 amino acids, including 8 cysteine residues. Source: E.coli Synonyms: Cerebral Dopamine Neurotrophic Factor, ARMETL1 AA Sequence: MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml. Calculated Molecular Weight: 18.5 kDa Accession Number: Q49AH0 Gene ID: 441549 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: This product is for research use only and not for cell, gene, or tissue therapy. crossreactivity: Mouse References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations Primer autor Venugopalan, P Titulo Transplanted neurons integrate into adult retinas and respond to light. Citar Nature Communications; 7 pg10472 PudMed id 26843334 Primer autor Tsenkina, Y Titulo EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury. Citar Cell death & disease; 6 pge1922 PudMed id 26469970