Neurotrophins

Recombinant Human CNTF

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Product Details

Catalogue Number: 450-13
Description:
Recombinant Human CNTF

CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion.

Source: E.coli

Synonyms: Ciliary Neurotrophic Factor

AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.

Calculated Molecular Weight: 22.8 kDa

Accession Number: P26441

Gene ID: 1270

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lagomarsino, V N
Title
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
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Neuron; 109(21) pg3402-3420.e9
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Singh, T
Title
Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated
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Scientific Reports; 11(1) pg18916
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Stoklund Dittlau, K
Title
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
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Stem Cell Reports; 16(9) pg2213-2227
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