Growth Factors & Cytokines

Recombinant Human CTGF

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Product Details

Catalogue Number: 120-19
Description:
Recombinant Human CTGF

CTGF is a member of the CCN family of secreted cysteine-rich regulatory proteins, and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial and epithelial cells, and binds to IGF, TGF-β1 and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans. CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Mature Human CTGF is a 38.0 kDa secreted protein containing 323 amino acid residues. CTGF is comprised of four distinct structural domains (modules), which are identified as IGF-Binding Protein (IGF-BP), von Willebrand Factor C (VWFC), Thrombospondin type I (TSP type I), and C-terminal cysteine knot-like (CTCK) domains. Full length CTGF can be proteolytically cleaved in certain tissues to yield N-terminal truncated isoforms, which, depending on the isoform, contain only the TSP type I and CTCK domains or contain only the CTCK domain. Recombinant Human CTGF is an 11.0 kDa protein consisting of 97 amino acid residues.

Source: E.coli

Synonyms: Connective Tissue Growth Factor, CCN2, Hypertrophic chondrocyte-specific protein 24 (HCS24)

AA Sequence: GKKCIRTPKI SKPIKFELSG CTSMKTYRAK FCGVCTDGRC CTPHRTTTLP VEFKCPDGEV MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 µg/ml.

Calculated Molecular Weight: 11 kDa

Accession Number: P29279

Gene ID: 1490

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Rao, K S
Title
CTGF-D4 Amplifies LRP6 Signaling to Promote Grafts of Adult Epicardial-derived Cells That Improve Cardiac Function After Myocardial Infarction.
Citation
Stem cells (Dayton, Ohio); 40(2) pg204-214
PubMed Id
First Author
Wu, Z
Title
CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway.
Citation
Cell Proliferation; 54(3) pge13001
PubMed Id
First Author
Wang, Y
Title
Exosomes from tendon stem cells promote injury tendon healing through balancing synthesis and degradation of the tendon extracellular matrix.
Citation
Journal of Cellular and Molecular Medicine; 23(8) pg5475-5485
PubMed Id